Congratulations to Penn University on firing a Nobel Prize winner. Penn brags about the now Nobel-winning work of a woman to whom they refused tenure in 1995.

[note] written by a guy who has 12 emails, because 11 emails already used to apply for journals and jobs and got rejected, pushing the limit until get clicked - viewed 20 millions of his writings.

UPDATE, THURSDAY 5.31pm OSLO and STOCKHOLM

Pfizer, BioNTech and biotech firm Promosome told a federal judge in San Diego, California, that they have agreed to end Promosome's lawsuit accusing the COVID vaccine makers of infringing a patent related to messenger RNA technology. The dominant patent of the m1Ψ invented by Katalin Karikó is as follows: US8278036B2. The date of her patent is October 2nd, 2012, EXACTLY 11 years before the announcement of the Nobel Prize for her and Drew Weissman.

HER PATENT, CLICK HERE

Nobel Prize winners Katalin Karikó and Drew Weissman pioneered the technology that produced a Covid-19 vaccine. Good description of shamelessness of ⁦Penn University⁩ in taking credit for Katalin Kariko and benefiting millions from her patent while demoting her. Genuinely shameless and disgusting. Absolutely no honor and dignity in ⁦Penn‘s behavior.

Traditional vaccines use killed or weakened viruses to develop immunity. Their development is resource intensive and takes a long time, involves large scale cell culture, antigen isolation, and further modification stages. The crux is that traditional vaccines can not be developed rapidly.

Hence, the need for a vaccine that can be developed rapidly gave rise to mRNA vaccines. These can be designed swiftly, are cheaper, can be manufactured faster and can be really helpful during pandemic outbreaks like Covid-19.

Research on mRNA vaccines has been in progress since the 1980s but it was Karikó and Weissman who noticed that if bases of mRNA are modified then the dendritic cells (that recognize foreign antigens) do not recognize injected mRNA as foreign and hence no inflammatory response.

Had Kariko gone cranky because of hardship in her earlier struggling days there might have been far more deaths due to Covid. Where other scientists saw dead ends, Karikó and Weissman saw hope. Salute to their work and indeed, research is nothing but a blind date with knowledge.

18 years after demoting someone for not doing “faculty level” science, University of Pennsylvania university managers will—without hesitation or compunction—claim that person’s Nobel-Prize winning, life-saving work to burnish their institutional reputation. Penn should apologize for demoting Karikó even while they hold the patent for the mRNA modification tech she helped discover (standard practice for universities). it would be nice to see a smidgeon of acknowledgment that the current tenure system doesn’t produce the best outcomes.

Katalin Karikó is an amazing case of perseverance and dedication. She did great work, despite having the deck stacked against her. Rejected - Fired, get Nobel Prize for saving BILLION OF LIVES [current worldwide population almost 8 billion]. Katalin Kariko, a professor kicked out of the tenure track has gotten the Nobel. In keeping with the Ivy ethos, Penn State brags about the now Nobel-winning work of a woman to whom they refused tenure in 1995.

about NFL, vaccine, and Taylor Alison Swift

Years ago, UChicago physics celebrating Maria Goeppert Mayer's Nobel without ever acknowledging they didn't pay her. There’s a ton of nuance here but I wouldn’t fire someone and take credit for their future success, especially when they are publicly saying how bad the bureaucracy was

The work that won today's The Nobel Prize Nobel in medicine (and saved billions of lives) "was summarily REJECTED by the journals Nature and Science". Keep trying. Journals are often RESISTANT to new ideas. The world puts up BARRIERS to see which of us is strong enough to keep pushing. When all the quitters quit, the barriers fall. Don't be a QUITTER. We're underinvesting in basic research, cutting off innovation and unforeseen breakthroughs.

"UPenn told me that they’d had a meeting and concluded that I was not of faculty quality. When I told them I was leaving, they laughed at me and said, ‘BioNTech doesn’t even have a website.’” [Katalin Kariko]

Days ago, I also once received a letter in a small town of Papua, a very secluded area, asking about access to my sheet [excel] list of 'respected-trusted doctors’ in Indonesia.”

A reminder to not let the fear of reject stop you. It is always so hard to be groundbreaking in academia. Journals rejecting GREAT papers. If this happened to you, you are in good company. Today’s Nobel Prize mini-scandal (over rejections of tenure and publication to the recipients) should give us all a bit of pause over mainstream assertions of authority and denial over new viewpoints—if countless other such cases over the years haven’t already done do.

8 Econ Nobel papers including legendary Milton Friedman’s that were rejected. Penn University Penn State University deny tenure to one of the recipients because her work wasn’t deemed “faculty quality.” More evidence that all of my rejected papers are misjudged genius. This is just further evidence of why we should stop “judging books by their cover.” Kinda like when multiple large publishing houses rejected the first Harry Potter manuscript out of hand, some children tale written by Exeter women named Joanne Rowling CH OBE FRSL JK. Rowling & Co., more than 600 million copies of Harry Potter titles have been sold worldwide, and they’ve been translated into 83 languages, and the films collectively made an astonishing US$7.73 billion worldwide.

There is no such thing as an overnight breakthrough. Thank you Katalin Kariko and Drew Weissman for continuing to do the work. The more I see these types of examples, the more I realize that this is a profession of persistence (90%) rather than finding cool ideas (10%). This is so much more important than people realize. Publication in the elite journals specifically and the broken peer review system exercise way too much influence in science today. A reminder to not let the fear of reject stop you.

The U.S. living donor HIV-to-HIV kidney transplant case series manuscript accepted by a Lancet journal was desk rejected after peer review by the American Journal of Transplantation, an editorial decision despite (+) reviews by a publication that does publish case reports. Yep.

The work by Hungarian scientist Katalin Karikó and her US counterpart David Weissman led to the rapid development of Covid vaccines based on mRNA by Moderna and BioNTech SE Pfizer BioNTech/Pfizer during 2020. Scientists whose work led to Covid mRNA vaccines win Nobel Prize.

=======

the author of this note was just get 4-5 clicks of substack when started years ago, until viral worldwide on live update Russia-Ukraine war, and other noted.

=======

=========END————

Thank you, as always, for reading. If you have anything like a spark file, or master thought list (spark file sounds so much cooler), let me know how you use it in the comments below. Thank you so much for letting me vent! If you enjoyed this article, you can give pledge to me (click PLEDGE button) or simply share this article with a friend. It helps me more than you realise.

If you enjoyed this post, please share it.

______________

Professor Hendrik, Professor Eric, and another person, Prof David A. Andelman, former Bureau Chief NYTimes recommended my substack, also some Chief Technology of Financial Times (FT) recommended my substack, not only subscribe. I'd be happy to get more & more PLEDGE and recommendations for better crafted writing (via Bank Central Asia (with my full-name ADI MULIA PRADANA, clearing code 0140119, account number 0201558866 or via STRIPE. For me, prefer Bank Central Asia).

If a friend sent this to you, you could subscribe here 👇. All content is free, and paid subscriptions are voluntary.

——————————————————————————————————

-prada- Adi Mulia Pradana is a Helper. Former adviser (President Indonesia) Jokowi for mapping 2-times election. I used to get paid to catch all these blunders—now I do it for free. Trying to work out what's going on, what happens next. Now figure out and or prevent catastrophic of everything.

(Very rare compliment and initiative pledge, and hopefully more readers more pledges to me. Thank you. My note-live blog about Russia - Ukraine already click-read 6 millions, not counting another note especially Live Update Substack (mostly Live Update Election or massive incident)

=======

Thanks for reading Prada’s Newsletter. I was lured, inspired by someone writer, his post in LinkedIn months ago, “Currently after a routine daily writing newsletter in the last 10 years, my subscriber reaches 100,000. Maybe one of my subscribers is your boss.”  After I get followed / subscribed by (literally) prominent AI and prominent Chief Product and Technology of mammoth global media (both: Sir, thank you so much), I try crafting more / better writing.

To get the ones who really appreciate your writing, and now prominent people appreciate my writing, priceless feeling. Prada ungated/no paywall every notes-but thank you for anyone open initiative pledge to me.

(Promoting to more engage in Substack) Seamless to listen to your favorite podcasts on Substack. You can buy a better headset to listen to a podcast here (GST DE352306207).

LIEBLINGSPRODUKTE click here

Listeners on Apple Podcasts, Spotify, Overcast, or Pocket Casts simultaneously. podcasting can transform more of a conversation. Invite listeners to weigh in on episodes directly with you and with each other through discussion threads. At Substack, the process is to build with writers. Podcasts are an amazing feature of the Substack. I wish it had a feature to read the words we have written down without us having to do the speaking. Thanks for reading Prada’s Newsletter.

Wants comfy jogging pants / jogginghose amid scorching summer or (one day) harsh winter like black jogginghose or khaki/beige jogginghose like this? click

Headset and Mic can buy in here, but not including this cat, laptop, and couch / sofa